Abstract:
New zinc (II), copper (II), nickel (II) and cobalt (III) complexes, [Zn (HL)
2
]I
2
(1), [Cu (HL)Cl
2
](2), [Cu (HL)Br
2
](3), [Cu (HL)(H
2
O)
2
](ClO
4
)
2
(4),
[Ni (HL)
2
]I
2
H
2
O(5), [Co(L)
2
]Cl (6), [Co(L)
2
]NO
3
(7), [Co(L)
2
]I[Co(L)
2
](I
3
)
(8) were obtained with 2-formylpyridine 4-allyl-S-methylisothiosemicarbazone
(HL). The isothiosemicarbazone ligand was characterized by NMR (
1
H and
13
C), IR spectroscopy and X-ray diffraction. All the complexes were character-
ized by elemental analysis, IR, UV–Vis, ESI-MS spectroscopy, molar conductiv-
ity, magnetic susceptibility measurements. X-ray diffraction analysis on the
monocrystal and powder elucidated the structure of the complexes 1,5,
7and 8.
The ligand and the complexes were tested for their antioxidant and antimi-
crobial activity against Staphylococcus aureus,Escherichia coli,Klebsiella
pneumoniae and Candida albicans. Also, the antiproliferative properties
of these compounds on human leukemia HL-60, human cervical epithelial
HeLa, human epithelial pancreatic adenocarcinoma BxPC-3, human
muscle rhabdomyosarcoma spindle, large multinucleated RD cells and
normal MDCK cells have been investigated. The nickel complex 5and
cobalt complexes 6,7showed promising antiproliferative activity and low
toxicity
