dc.contributor.author |
Gulea, Aurelian |
|
dc.contributor.author |
Fuior, Arcadie |
|
dc.contributor.author |
Garbuz, Olga |
|
dc.contributor.author |
Bulimaga, Valentina |
|
dc.contributor.author |
Zosim, Liliana |
|
dc.contributor.author |
Cebotari, Diana |
|
dc.contributor.author |
Toderaș, Ion |
|
dc.date.accessioned |
2021-10-19T10:33:00Z |
|
dc.date.available |
2021-10-19T10:33:00Z |
|
dc.date.issued |
2021 |
|
dc.identifier.citation |
FUIOR, Arcadie, GULEA, Aurelian, GARBUZ, Olga et al. Screening of biological properties of MoV2O2S2- and MoV2O4-based coordination complexes: Investigation of antibacterial, antifungal, antioxidative and antitumoral activities versus growing of Spirulina platensis biomass. In: Journal of Inorganic Biochemistry. 2021. ISSN 0162-0134. |
en |
dc.identifier.issn |
ISSN 0162-0134 |
|
dc.identifier.uri |
https://doi.org/10.1016/j.jinorgbio.2021.111627 |
|
dc.identifier.uri |
http://dspace.usm.md:8080/xmlui/handle/123456789/4943 |
|
dc.description.abstract |
This paper deals with the biological potential of coordination compounds based on binuclear core [MoV2O2E2]2+ (E = O or S) coordinated with commercially available ligands such as oxalates (Ox2−), L-cysteine (L-cys2−), L-histidine (L-his−), Iminodiacetate (IDA2−), Nitrilotriacetate (HNTA2− or NTA3−) or ethylenediamine tetraacetate (EDTA4−) by means of various in vitro assays in a screening approach. Results suggest that the obtained complexes show weak antibacterial and antifungal properties while not being cytotoxic on cancerous and mammalian cells. In contrast, [Mo2O2E2(L-cys)2]2− complexes stand out as powerful antioxidant, whereas [Mo2O2E2(EDTA)]2− associating tetraphenylphosphonium counter-cations display strong antibiotic activity. Finally, some complexes have evidenced a positive activity towards the growing of spirulina platensis together with a modification of the proportions of biological components inside the cells. These findings reveal promising bioactivity of the bridged binuclear Mo(+V) cores inside complexes and encourage further research for new highly active yet non-toxic molecules for biological and biomedical applications. |
en |
dc.language.iso |
en |
en |
dc.publisher |
Elsevier |
en |
dc.subject |
Molybdenum |
en |
dc.subject |
clusters |
en |
dc.subject |
Cytotoxicity |
en |
dc.subject |
Molybdenum Cluster Complex Cytotoxicity Antibiotic activity Spirulina platensis |
en |
dc.subject |
Antibiotic activity |
en |
dc.subject |
Spirulina platensis |
en |
dc.title |
SCREENING OF BIOLOGICAL PROPERTIES OF MOV2O2S2- AND MOV2O4-BASED COORDINATION COMPLEXES: INVESTIGATION OF ANTIBACTERIAL, ANTIFUNGAL, ANTIOXIDATIVE AND ANTITUMORAL ACTIVITIES VERSUS GROWING OF SPIRULINA PLATENSIS BIOMASS |
en |
dc.type |
Article |
en |