The paper presents the synthesis of the ligand 5-nitrofuran-2-carbaldehyde N(4)-allyl-3-thiosemicarbazone (HL) and
eight coordination compounds of copper(II) and nickel(II) with this ligand. The structure of thiosemicarbazone HL was
studied using 1
H and 13С NMR spectroscopy. For the synthesized compounds their antimicrobial and antifungal activity
was studied on a series of standard strains. For HL and Cu(HL)2(NO3)2 the antitumor activity towards human leukemia
HL-60 cells was estimated. It was established that coordination compounds manifest better activity than free ligand.
Lucrarea conţine descrierea sintezeiN(4)-alil-3-tiosemicarbazonei 5-
nitrofuran-2-carbaldehidei (HL)şi a optcompuşi coordinativi ai cuprului(II) şi nichelului(II) cu acestli gand. Structura tiosemicarbazoneiHLa fost stabilită în baza datelor spectroscopiei
RMN1H şi C13. A fost studiată activitatea anti microbiană şi antifungică a compuşilor sintetizaţi faţă de un spectru larg de tulpini
standard. Cercetarea proprităţilor anti proliferative a arătat că compuşii HL şi Cu(HL)2(NO3)2 inhibă creşterea şi multiplicarea celulelor leucemiei mieloide umaneHL-60. S-a stabilit că compuşii
coordinativi manifestă o activitate mai bună decât ligandul.
