SYNTHESIS AND ANTITUMOR ACTIVITY OF COPPER, NICKEL AND COBALT COORDINATION COMPOUNDS WITH 1-(2-HYDROXYPHENYL)ETHANONE N(4)-ALLYL-3-THIOSEMICARBAZONE

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dc.contributor.author Graur, Vasilii
dc.contributor.author Savcin Serghei
dc.contributor.author Tsapklov Victor
dc.contributor.author Gulea, Aurelian
dc.date.accessioned 2016-01-22T11:46:34Z
dc.date.available 2016-01-22T11:46:34Z
dc.date.issued 2015
dc.identifier.citation GRAUR, V., SAVCIN, S. et al. Synthesis and antitumor activity of copper, nickel and cobalt coordination compounds with 1-(2-hydroxyphenyl)ethanone N-(4)-allyl-3-thiosemicarbazone. In Studia Universitatis Moldaviae. Seria Ştiinţe reale şi naturii. Biologie. Chimie. 2015, nr 1(81). PP.210-215 en
dc.identifier.issn 1814-3237
dc.identifier.uri http://dspace.usm.md:8080/xmlui/handle/123456789/266
dc.identifier.uri http://studiamsu.eu/nr-1-81-2015/
dc.description.abstract The paper presents the synthesis of the ligand 1-(2-hydroxyphenyl)ethanone N(4)-allyl-3-thiosemicarbazone (H 2 L) and six coordination compounds of copper, nickel and cobalt with this ligand. The structure of thiosemicarbazone H 2 L was studied using 1 H and 13 С NMR spectroscopy. The synthesized coordination compounds were studied using elemental analysis, gravimetric analysis of water content, molar conductivity, and magnetochemistry. For H 2 L the antitumor activity towards human leukemia HL-60 cells and cervical cancer HeLa cells was dete rmined. It was established that the substitution of hydrogen atom with methyl group in the azomethinic fragment leads to the growth of antitumor activity.
dc.description.abstract Lucrarea conţine descrierea sintezei N(4)-alil-3-tiosemicarbazonei 1-(2-hidroxifenil)etanonei (H2L) şi a şase compuşi coordinativi ai cuprului, nichelului şi cobaltului cu acest ligand. Structura tiosemicarbazonei H2L a fost stabilită în baza datelor spectroscopiei RMN 1H şi 13C. Compuşi coordinativi au fost studiaţi cu ajutorul analizei elementale, analizei gravimetrice a conţinutului de apă, conductivitaţii molare şi magnetochimiei. Pentru H2L a fost determinată activitatea antitumorală faţă de celulele leucemiei umane HL-60 şi ale cancerului cervical HeLa. S-a stabilit că înlocuirea atomului de hidrogen cu o grupare metil în fragmentul azomethinic conduce la creşterea activitaţii antitumorale.
dc.language.iso en en
dc.publisher CEP USM en
dc.subject complexes en
dc.subject thioxemicarbazone en
dc.subject complecşi en
dc.subject activitate antitumorală en
dc.title SYNTHESIS AND ANTITUMOR ACTIVITY OF COPPER, NICKEL AND COBALT COORDINATION COMPOUNDS WITH 1-(2-HYDROXYPHENYL)ETHANONE N(4)-ALLYL-3-THIOSEMICARBAZONE en
dc.title.alternative Sinteza şi activitatea antitumorală a compuşilor complecşi ai cuprului, nichelului şi cobaltului cu N(4)-alil-3-tiosemicarbazona 1-(2-hidroxifenil)etanonei en
dc.type Article en


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