dc.contributor.author |
Graur, Vasilii |
|
dc.contributor.author |
Savcin Serghei |
|
dc.contributor.author |
Tsapkov Victor |
|
dc.contributor.author |
Gulea, Aurelian |
|
dc.date.accessioned |
2016-01-22T11:46:34Z |
|
dc.date.available |
2016-01-22T11:46:34Z |
|
dc.date.issued |
2015 |
|
dc.identifier.citation |
GRAUR, V., SAVCIN, S. et al. Synthesis and antitumor activity of copper, nickel and cobalt coordination compounds with 1-(2-hydroxyphenyl)ethanone N-(4)-allyl-3-thiosemicarbazone. In Studia Universitatis Moldaviae. Seria Ştiinţe reale şi naturii. Biologie. Chimie. 2015, nr 1(81). PP.210-215 |
en |
dc.identifier.issn |
1814-3237 |
|
dc.identifier.uri |
http://dspace.usm.md:8080/xmlui/handle/123456789/266 |
|
dc.identifier.uri |
http://studiamsu.eu/nr-1-81-2015/ |
|
dc.description.abstract |
The paper presents the synthesis of the ligand 1-(2-hydroxyphenyl)ethanone N(4)-allyl-3-thiosemicarbazone (H
2
L)
and six coordination compounds of copper, nickel and cobalt with this ligand. The structure of thiosemicarbazone H
2
L
was studied using
1
H and
13
С
NMR spectroscopy. The synthesized coordination compounds were studied using elemental
analysis, gravimetric analysis of water content,
molar conductivity, and magnetochemistry. For H
2
L the antitumor
activity towards human leukemia HL-60 cells
and cervical cancer HeLa cells was dete
rmined. It was established that the
substitution of hydrogen atom with methyl group in the azomethinic fragment leads to the growth of antitumor activity. |
|
dc.description.abstract |
Lucrarea conţine descrierea sintezei N(4)-alil-3-tiosemicarbazonei 1-(2-hidroxifenil)etanonei (H2L) şi a şase compuşi coordinativi ai cuprului, nichelului şi cobaltului cu acest ligand. Structura tiosemicarbazonei H2L a fost stabilită în baza datelor spectroscopiei RMN 1H şi 13C. Compuşi coordinativi au fost studiaţi cu ajutorul analizei elementale, analizei gravimetrice a conţinutului de apă, conductivitaţii molare şi magnetochimiei. Pentru H2L a fost determinată activitatea antitumorală faţă de celulele leucemiei umane HL-60 şi ale cancerului cervical HeLa. S-a stabilit că înlocuirea atomului de hidrogen cu o grupare metil în fragmentul azomethinic conduce la creşterea activitaţii antitumorale. |
|
dc.language.iso |
en |
en |
dc.publisher |
CEP USM |
en |
dc.subject |
complexes |
en |
dc.subject |
thioxemicarbazone |
en |
dc.subject |
complecşi |
en |
dc.subject |
activitate antitumorală |
en |
dc.title |
SYNTHESIS AND ANTITUMOR ACTIVITY OF COPPER, NICKEL AND COBALT COORDINATION COMPOUNDS WITH 1-(2-HYDROXYPHENYL)ETHANONE N(4)-ALLYL-3-THIOSEMICARBAZONE |
en |
dc.title.alternative |
Sinteza şi activitatea antitumorală a compuşilor complecşi ai cuprului, nichelului şi cobaltului cu N(4)-alil-3-tiosemicarbazona 1-(2-hidroxifenil)etanonei |
en |
dc.type |
Article |
en |