SINTEZA 4-(2-PIRIDIL)TIOSEMICARBAZIDEI ŞI A UNOR 4-(2-PIRIDIL) TIOSEMICARBAZONE ŞI ACTIVITATEA ANTIPROLIFERATIVĂ A CELULELOR LEUCEMICE HL-60

Abstract

In the present work it was proposed a new method of synthesis of 4-(2-pyridyl) thiosemicarbazide and were synthesized eight 4-(2-pyridyl) thiosemicarbazons by the known method. The identity and purity of organic obtained compounds were demonstrated by chromatography, melting point, as well as by 13C and 1H NMR spectra. The synthesized substances were tested, studying the antiproliferative activity of HL-60 leukemia cells. The properties of compounds represent an interest for medicine in terms of expanding of an arsenal of inhibitors in human leukemia HL-60 myeloid, thiosemicarbazone manifest comparable activity with the one of such drugs as doxorubicin (Doxo) used in medicine for leukemia treatment.