Synthesis, Caracterization, Antimicrobial and antiproliferative Activity Evaluation of Cu(II), Co(II), Zn(II), Ni(II) and Pt(II) Complexes with Isoniazid - Derived Compound

Show simple item record

dc.contributor.author Pahonţu, Elena
dc.contributor.author Ilieş, Diana-Carolina
dc.contributor.author Shova, Sergiu
dc.contributor.author Oprean, Camelia
dc.contributor.author Păunescu, Vergil
dc.contributor.author Olaru, Octavian Tudorel
dc.contributor.author Rădulescu, Flavian Ştefan
dc.contributor.author Gulea, Aurelian
dc.contributor.author Roşu, Tudor
dc.contributor.author Drăgănescu, Doina
dc.date.accessioned 2019-11-18T11:45:03Z
dc.date.available 2019-11-18T11:45:03Z
dc.date.issued 2017
dc.identifier.citation Pahonţu, E., Gulea, A. et al. Synthesis, Caracterization, Antimicrobial and antiproliferative Activity Evaluation of Cu(II), Co(II), Zn(II), Ni(II) and Pt(II) Complexes with Isoniazid - Derived Compound. In: Molecules . 2017, nr. 22 (4), pp. 650. ISSN 1420-3049. en
dc.identifier.issn 1420-3049
dc.identifier.uri http://dspace.usm.md:8080/xmlui/handle/123456789/2307
dc.description.abstract Hydrazone complexes of Cu(II), Co(II), Zn(II), Ni(II) and Pt(II) with N-isonicotinoyl-N′-(3-metoxy-2 hydroxybenzaldehyde)-hydrazone (HL) were synthesized and characterized by different physico-chemical techniques including elemental and thermal analysis, magnetic susceptibility measurements, molar electric conductivity, as well as IR (infrared), 1H-NMR and 13C-NMR (hydrogen and carbon nuclear magnetic resonance, UV-Vis (ultraviolet-visible), FAB (fast atom bombardment), EPR (electron paramagnetic resonance), and mass spectroscopies. The crystal structure of ligand was determined by single crystal X-ray diffraction studies. Spectral data showed that hydrazone behaves as an ONO tridentate ligand through the azomethine nitrogen, phenolate and keto oxygen atoms. For the copper(II) complexes, metal–ligand bonding parameters were evaluated from the EPR spectra. These parameters indicate the presence of in-plane π bonding. In addition, the f values of complexes 1–4 indicate small distortion from planarity. The effect of these complexes on proliferation of human breast cancer (MCF-7 and SKBR-3), human melanoma (A375), lung adenocarcinoma cells (NCI-H1573) and their antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Candida albicans strains were studied and compared with those of free ligand. The ligand and complexes 1–3 showed significant antimicrobial activity against the Gram-positive bacteria Staphylococcus aureus and Candida albicans in comparison to the control drugs. The complexes 2–4 could be potential antitumor agents, leading to a significant improvement of the cytotoxic activity when compared with HL. en
dc.language.iso en en
dc.publisher Molecular Diversity Preservation International (MDPI) en
dc.subject copper(II) en
dc.subject lung adenocarcinoma cell NCI-H1573 en
dc.subject human melanoma A375 en
dc.subject cobalt(II) en
dc.subject zinc(II) en
dc.subject human breast SKBR-3 and MCF-7 en
dc.subject nickel(II) and platinum(II) complexes en
dc.subject antimicrobial activity en
dc.title Synthesis, Caracterization, Antimicrobial and antiproliferative Activity Evaluation of Cu(II), Co(II), Zn(II), Ni(II) and Pt(II) Complexes with Isoniazid - Derived Compound en
dc.type Article en


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account