SYNTHESIS AND BIOLOGICAL ACTIVITY OF  2-FORMYLPYRIDINE N(4)-ALLYL-3-SELENO-SEMICARBAZONE  AND ITS COPPER COORDINATION COMPOUND

Gudumac, Valentin; Zariciuc, Elena; Graur, Vasilii; Gulea, Aurelian; Garbuz, Olga

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dc.contributor.author	Graur, Vasilii
dc.contributor.author	Garbuz, Olga
dc.contributor.author	Zariciuc, Elena
dc.contributor.author	Gudumac, Valentin
dc.contributor.author	Gulea, Aurelian
dc.date.accessioned	2019-04-10T11:46:16Z
dc.date.available	2019-04-10T11:46:16Z
dc.date.issued	2015
dc.identifier.citation	GRAUR, V., GARBUZ, O. et al. Synthesis and biological activity of 2-formylpyridine n(4)-allyl-3-seleno-semicarbazone and its copper coordination compound. In:Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţele vieţii. 2015, nr. 3. p. 135-142. IISSN 1857-064X.	en
dc.identifier.issn	1857-064X
dc.identifier.uri	http://dspace.usm.md:8080/xmlui/handle/123456789/2020
dc.description.abstract	The paper presents the synthesis of the 2-formylpyridine N(4)-allyl-3-seleno-semicarbazone that was studied using NMR spectroscopy. This ligand was used for the synthesis of a copper(II) chloride coordination compound. The study of antimicrobial and antifungal activities showed that these substances possess bacteriostatic and bactericidal activities towards a series of gram-positive and gram-negative bacteria and fungi in the range of concentration 0.7-500μg/mL. The activity of the copper(II) coordination compound towards gram-negative microorganisms significantly exceeds the activity of the ligand. The antioxidant activity of the synthesized selenosemicarbazones exceeds the activity of the coordination compound. These substances inhibit proliferation of MeW-164, HL-60 and HeLa tumor cells. 16 references, 1 table, 7 schemes	en
dc.language.iso	en	en
dc.subject	selenosemicarbazones	en
dc.subject	copper complexes	en
dc.subject	antioxidant activity	en
dc.subject	antimicrobial activity	en
dc.subject	antitumor activity	en
dc.title	SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-FORMYLPYRIDINE N(4)-ALLYL-3-SELENO-SEMICARBAZONE AND ITS COPPER COORDINATION COMPOUND	en
dc.type	Article	en