În prezenta lucrare a fost realizată sinteza1,1-dimetil-3-(3-metil-5-sulfanil-4H-1,2,4-triazol-4-il)tioureei (5) şi a1,1-dimetil-3-[3-metil-5-(metilsulfanil)-4H-1,2,4-triazol-4-il]tioureei (6), ale căror structuri au fost stabilite cu ajutorul spectrelor 1H-RMN şi 13C-RMN. Pe celule de cancer cervical substanţele iodhidrat de 3-metil-5-(metilsulfanil)-4H-1,2,4-triazol-4-amină 2) şi 6 au demonstrat o activitate nesemnificativă. Disulfura de tetrametiltiuram(DTMT) a demonstrat rezultate antibacteriene bune CMI 0,0007 mg/mL,iar substanţele 6 şi 2 au CMI 0,007 mg/mL şi, respectiv, 0,06 mg/mL. Tioureea 6 are proprietăţi antioxidante IC50= 29 μM/L aproximativ egale cu ale troloxului.A fost realizată sinteza N-[4-(3-metil-7H-1,2,4]triazolo[3,4-b][1,3,4]-tiadiazin-6-il)fenil]-2-[1-(piridin--il)etiliden]hidrazincarbotioamidei (11) şi a bazei Schiff [{[3-metil-5-(metilsulfanil)-4H-1,2,4-triazol-4-il]imino}metil]fenol (3). La compusul 3a fost efectuată difracţia cu raze X în monocristal.
In the present work the synthesis of 1,1-dimethyl-3-(3-methyl
-5-sulfanyl-4H-1,2,4-triazol
-
4
-
yl)thiourea (
5
) and
1,1
-
dimethyl
-
3
-
[3
-
methyl
-
5
-
(methylsulfanyl)
-
4
H
-
1,2,4
-
triazol
-
4
-
yl]thiourea (
6
) was carried out. The structures were
determined using
1
H;
13
C
-
NMR spectra. For cells HeLa of cervical cancer, substances 3
-
methyl
-
5
-
(methylsulfanyl)
-
4
H
-
1,2,4
-
triazol
-
4
-
aminohydroiodide (
2
) and
6
have demonstrated not pronou
nced activity. Tetramethylthiuram disulfide
(DTMT) showed good antibacterial activity MIC 0.0007 mg/mL, but substances
6
and
2
have MIC 0.007 mg/mL and
0.06 mg/mL respectively. The thiourea
6
has antioxidant properties IC
50
= 29 μM/L approximately equal to
trolox.
Synthesis of N
-
[4
-
(3
-
methyl
-
7
H
-
[1,2,4]triazolo[3,4
-
b][1,3,4]
-
thiadiazin
-
6
-
yl)phenyl]
-
2
-
[1
-
(pyridin
-
2
-
yl)ethylidene]
hydrazinecarbothioamide (
11
) and Schiff base: 2
-
[{[3
-
methyl
-
5
-
(methyl
-
sulfanyl)
-
4
H
-
1,2,4
-
triazol
-
4
-
yl]imino}methyl]
phenol (
3
) was carried out. The compound
3
was studied by conducted single
-
crystal X
-
ray diffraction.