dc.contributor.author |
Ulchina, Ianina |
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dc.contributor.author |
Graur, Vasilii |
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dc.contributor.author |
Țapcov, Victor |
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dc.contributor.author |
Ciumacov, Iurie |
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dc.contributor.author |
Garbuz, Olga |
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dc.contributor.author |
Burduniuc, Olga |
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dc.contributor.author |
Ceban, Emil |
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dc.contributor.author |
Gulea, Aurelian |
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dc.date.accessioned |
2023-10-26T09:13:04Z |
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dc.date.available |
2023-10-26T09:13:04Z |
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dc.date.issued |
2022 |
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dc.identifier.citation |
ULCHINA, Ianina, GRAUR, Vasilii , ȚAPCOV, Victor , CIUMACOV, Iurie, GARBUZ, Olga, BURDUNIUC, Olga, CEBAN, Emil, GULEA, Aurelian. Introducing N-Heteroaromatic Bases into Copper(II) Thiosemicarbazon Complexes: A Way to Change their Biological Activity. În: ChemistryOpen, 2022, vol. 11, pp. 1-7. ISSN 2191-1363 |
en |
dc.identifier.issn |
2191-1363 |
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dc.identifier.uri |
http://dspace.usm.md:8080/xmlui/handle/123456789/11472 |
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dc.identifier.uri |
https://doi.org/10.1002/open.202200208 |
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dc.description.abstract |
Three new copper(II) complexes, [Cu(1,10-Phen)(L)] (1), [Cu(2,2’- Bpy)(L)] (2) and [Cu(3,4-Lut)(L)] (3), where H2L=2-[(2,4- dihydroxyphenyl)methylidene]-N-(prop-2-en-1-yl)hydrazine-1- carbothioamide, 1,10-Phen=1,10-phenanthroline, 2,2’-Bpy= 2,2’-bipyridine, 3,4-Lut=3,4-lutidine, have been synthesized and characterized by elemental analysis, FTIR spectroscopy and single crystal X-ray crystallography (1, 2). All compounds are mononuclear. The introduction of a monodentate N-heteroaromatic base (3,4-dimethylpyridine) has led to a significant increase of antimicrobial activity against Gram-negative Escherichia coli and antifungal activity against Candida albicans compared to the pro-ligand and the precursor complex [Cu- (L)H2O]. The introduction of bidentate N-heteroaromatic bases did not lead to such increase of antimicrobial and antifungal activities. Moreover, complex 3 surpasses the inhibitory activity of tetracycline toward Enterobacter cloacae and the inhibitory activity of fluconazole toward Candida parapsilosis and Cryptococcus neoformans. The study of antioxidant activity against cation radicals ABTS* + showed that complexes 1–3 are more active than Trolox, but only introduction of the monodentate Nheteroaromatic base (3,4-dimethylpyridine) led to the increase of antioxidant properties compared to the precursor complex. |
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dc.description.sponsorship |
This work was fulfilled with the financial support of the ANCD projects
20.80009.5007.10 and 20.80009.5007.15. |
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dc.language.iso |
en |
en |
dc.subject |
antimicrobial and antifungal activities |
en |
dc.subject |
antioxidants |
en |
dc.subject |
copper complex |
en |
dc.subject |
N-heteroaromatic bases |
en |
dc.subject |
thiosemicarbazone |
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dc.title |
INTRODUCING N-HETEROAROMATIC BASES INTO COPPER(II) THIOSEMICARBAZON COMPLEXES: A WAY TO CHANGE THEIR BIOLOGICAL ACTIVITY |
en |
dc.type |
Article |
en |