Abstract:
2-Oxopropanoic acid reacts in ethanol with N-(prop-2-en-1-yl)hydrazinecarbothioamide in a 1 : 1
mole ratio to form thiosemicarbazone H2L. Coordination compounds Cu(HL)X [X = Cl–, Br–, NO 3
–], Cu(H 2O)(L),
Ni(HL)2, Co(HL)2X [X = Cl–, Br–], and Fe(HL)2X [X = NO3
–
, Br–] are formed in the reactions of H2L with copper(II),
nickel(II), cobalt(II), and iron(III) salts. The reactions of Cu(H2O)(L) with imidazole (Im) and 3,4-dimethylpyridine
(3,4-Lut) result in mixed-ligand complexes Cu(A)(L) [A = Im, 3,4-Lut]. The structures of two copper complexes
were determined by single crystal X-ray diffraction analysis. The synthesized complexes exhibit selective antimi-
crobial and antifungal activity in the concentration range of 15.62–1000 μg/mL. The introduction of amines into
the inner sphere of copper complexes leads to an increase in the antimicrobial activity.